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J Dent Res. 2010 Mar;89(3):219-29. doi: 10.1177/0022034509359125. Epub 2010 Feb 5.

Factors affecting wound healing.

Author information

1
Center for Wound Healing and Tissue Regeneration, Department of Periodontics, College of Dentistry (MC 859), University of Illinois at Chicago, 801 S. Paulina Ave., Chicago, IL 60612, USA.

Abstract

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.

PMID:
20139336
PMCID:
PMC2903966
DOI:
10.1177/0022034509359125
[Indexed for MEDLINE]
Free PMC Article

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