Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. doi: 10.1016/j.bmcl.2010.01.045. Epub 2010 Jan 20.

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.

Author information

1
Almirall Research Center, Almirall S.A., Ctra. Laureà Miró 408, St. Feliu de Llobregat, E-08980 Barcelona, Spain. paulroberteastwood@yahoo.co.uk

Abstract

The synthesis and SAR of a series of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent A(2B) adenosine receptor antagonists is described. Several compounds showed good selectivity versus other adenosine receptors. The potent and selective analogue 9 was shown to have good oral bioavailability in the rat.

PMID:
20137946
DOI:
10.1016/j.bmcl.2010.01.045
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center