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Respirology. 2010 May;15(4):587-95. doi: 10.1111/j.1440-1843.2009.01699.x. Epub 2010 Jan 27.

Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions.

Author information

1
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia. peter.eastwood@health.wa.gov.au

Abstract

Obstructive sleep apnoea (OSA) is a common disease, recognized as an independent risk factor for a range of clinical conditions, such as hypertension, stroke, depression and diabetes. Despite extensive research over the past two decades, the mechanistic links between OSA and other associated clinical conditions, including metabolic disorders and cardiovascular disease, remain unclear. Indeed, the pathogenesis of OSA itself remains incompletely understood. This review provides opinions from a number of leading experts on issues related to OSA and its pathogenesis, interaction with anaesthesia, metabolic consequences and comorbidities, cardiovascular disease, genetics, measurement and diagnosis, surgical treatment and pharmacotherapeutic targets.

PMID:
20136736
PMCID:
PMC4342116
DOI:
10.1111/j.1440-1843.2009.01699.x
[Indexed for MEDLINE]
Free PMC Article

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