Format

Send to

Choose Destination
J Med Food. 2010 Feb;13(1):1-5. doi: 10.1089/jmf.2009.1142.

A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice.

Author information

1
Department of Food and Nutrition, College of Health Science, Korea University, Seoul, Republic of Korea.

Abstract

Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0 g/kg/day were 18.9% (P < .05), 60.0% (P < .001), and 67.5% (P < .001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.

PMID:
20136429
DOI:
10.1089/jmf.2009.1142
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center