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Org Biomol Chem. 2010 Feb 21;8(4):739-50. doi: 10.1039/b918488k. Epub 2009 Dec 3.

Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology.

Author information

1
Department Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany.

Abstract

Cholesterol-derived hormones, the dafachronic acids, play a major role in controlling the life cycle and initiating dauer larva formation of the nematode Caenorhabditis elegans. This Perspective describes recent progress in the synthesis of these steroid hormones and their biological function.

PMID:
20135027
DOI:
10.1039/b918488k
[Indexed for MEDLINE]

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