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Biochim Biophys Acta. 2010 Aug;1804(8):1591-603. doi: 10.1016/j.bbapap.2010.01.021. Epub 2010 Feb 2.

Sirtuin chemical mechanisms.

Author information

1
Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10065, USA. aas2004@med.cornell.edu

Abstract

Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are universally able to bind NAD(+), and activate it to effect ADP-ribosylation of cellular nucleophiles. The most commonly observed sirtuin reaction is the ADP-ribosylation of acetyllysine, which leads to NAD(+)-dependent deacetylation. Other types of ADP-ribosylation have also been observed, including protein ADP-ribosylation, NAD(+) solvolysis and ADP-ribosyltransfer to 5,6-dimethylbenzimidazole, a reaction involved in eubacterial cobalamin biosynthesis. This review broadly surveys the chemistries and chemical mechanisms of these enzymes.

PMID:
20132909
PMCID:
PMC2886189
DOI:
10.1016/j.bbapap.2010.01.021
[Indexed for MEDLINE]
Free PMC Article

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