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J Dig Dis. 2010 Feb;11(1):2-11. doi: 10.1111/j.1751-2980.2009.00408.x.

Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention.

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Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger, Magdeburg, Germany.


Gastric cancer in the absence of strategies implemented for early detection continues to have a dismal prognosis. There are limited options for a curative therapy once patients present with clinical manifestations of this malignant disease. Helicobacter pylori (H. pylori) infection plays a key role in gastric carcinogenesis, supported by epidemiological, preclinical and clinical studies. The recognition of H. pylori infection as a critical risk factor in the development of gastric cancer opens the chance for new venues in prevention strategies.

[Indexed for MEDLINE]

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