Market capitalization of top-tier pharmaceutical companies in January 2001 and September 2009. Cumulative loss in market capitalization for these companies over the period is $626 billion. Ticker symbols are as follows: ABT, Abbott; AZN, AstraZeneca; BMY, Bristol-Myers Squibb; GSK, GlaxoSmithKline; LLY, Lilly; MRK, Merck; PFE, Pfizer; SGP, Schering-Plough; WYE, Wyeth. Data from http://www.valueline.com; Tufts Center for the Study of Drug Development analysis.