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Thromb Res. 2010 Apr;125 Suppl 1:S23-5. doi: 10.1016/j.thromres.2010.01.027. Epub 2010 Feb 4.

Protein-phospholipid interactions in blood clotting.

Author information

1
Department of Biochemistry, College of Medicine, University of Illinois at Urbana-Champaign, 506 S. Mathews Ave., Urbana, IL, USA. jhmorris@illinois.edu

Abstract

Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackling this question using a combination of approaches, including nanoscale membrane bilayers, solid-state NMR, and large-scale molecular dynamics simulations. These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions.

PMID:
20129649
PMCID:
PMC2838931
DOI:
10.1016/j.thromres.2010.01.027
[Indexed for MEDLINE]
Free PMC Article

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