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Cancer Cell. 2010 Jan 19;17(1):5-6. doi: 10.1016/j.ccr.2009.12.032.

A tumor suppressor SIRTainty.

Author information

1
Department of Pediatrics, Robert F Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. p-schumacker@northwestern.edu

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

PMID:
20129243
DOI:
10.1016/j.ccr.2009.12.032
[Indexed for MEDLINE]
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