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Mol Cell. 2010 Jan 15;37(1):5-6. doi: 10.1016/j.molcel.2009.12.028.

Histone acetylation by HBO1 tightens replication licensing.

Author information

1
Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

Abstract

In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage.

PMID:
20129050
PMCID:
PMC2822430
DOI:
10.1016/j.molcel.2009.12.028
[Indexed for MEDLINE]
Free PMC Article

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