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World J Gastroenterol. 2010 Feb 7;16(5):583-7.

Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.

Author information

  • 1Gastroenterology and Nutrition Department, Saint Antoine Hospital, Pierre et Marie Curie-Paris6 University, AP-HP, 184 rue du Faubourg Saint-Antoine, 75571, Paris, France. sokol_harry@yahoo.fr

Abstract

AIM:

To evaluate whether crypt abscesses from inflammatory bowel disease (IBD) patients contain bacteria and to establish their nature.

METHODS:

We studied 17 ulcerative colitis patients, 11 Crohn's disease patients, 7 patients with acute self-limited colitis (ASLC) and normal colonic biopsies from 5 subjects who underwent colonoscopy for colon cancer screening. A fluorescent in situ hybridization technique was applied to colonic biopsies to assess the microbiota composition of the crypts and crypt abscesses.

RESULTS:

Crypts colonized by bacteria were observed in 42.9% and 3.6% of ASLC and IBD patients, respectively (P = 0.019). Crypt abscesses colonized by bacteria were observed in 28.6% and 0.0% of ASLC and IBD patients, respectively (P = 0.035).

CONCLUSION:

These results do not support the hypothesis that crypt abscesses in IBD are the result of localized dysbiosis arising from persistence of living bacteria colonizing the crypts.

PMID:
20128026
PMCID:
PMC2816270
[PubMed - indexed for MEDLINE]
Free PMC Article
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