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Cancer. 2010 Feb 15;116(4 Suppl):1075-83. doi: 10.1002/cncr.24795.

Anti-prostate-specific membrane antigen-based radioimmunotherapy for prostate cancer.

Author information

1
Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, USA. stt2007@med.cornell.edu

Abstract

Despite recent advances, advanced prostate cancer is suboptimally responsive to current chemotherapeutic agents. Radiolabeled monoclonal antibody therapy that targets prostate-specific membrane antigen (PSMA) shows promise and is an area of active investigation. J591 is a deimmunized IgG monoclonal antibody developed to target the extracellular domain of PSMA. Preclinical and early phase clinical studies using radiolabeled J591 have demonstrated efficacy in targeting tumor cells and decreasing levels of prostate-specific antigen. Radiolabeled J591 is well-tolerated, nonimmunogenic, and can be administered in multiple doses. The dose-limiting toxicity is reversible myelosuppression with little nonhematologic toxicity. Future studies will include approaches to optimize patient selection and incorporate novel strategies to improve the success of anti-PSMA radioimmunotherapy.

PMID:
20127956
PMCID:
PMC2820151
DOI:
10.1002/cncr.24795
[Indexed for MEDLINE]
Free PMC Article

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