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Clin Cardiol. 2010 Mar;33(3):E63-8. doi: 10.1002/clc.20576.

Prevention of contrast-induced nephropathy: a single center randomized study.

Author information

1
Divisione di Cardiologia, Dipartimento di Medicina, Chirurgia, Odontoiatria, Ospedale San Paolo, University of Milan, Via A. di Rudiní 8, Milan, Italy. diegocarlo.castini@fastwebnet.it

Abstract

BACKGROUND:

Contrast-induced nephropathy (CIN) is the third cause of acute deterioration of renal function in hospitalized patients.

HYPOTHESIS:

The purpose of the study was to compare the efficacy of saline infusion, saline infusion plus N-acetylcysteine (NAC), and sodium bicarbonate (SB) infusion to prevent CIN in patients undergoing coronary angiography and/or percutaneous coronary intervention.

METHODS:

We prospectively studied 156 patients with a baseline creatinine level > or = 1.2 mg/dL. The primary endpoint was the development of CIN, defined as an increase in serum creatinine concentration > or = 25% over the baseline value within 5 days from contrast exposure.

RESULTS:

Contrast-induced nephropathy developed in 23 patients (14.7%). Incidence of the primary endpoint was similar in the 3 groups of treatment, occurring in 7 patients (14%) in the saline infusion group, in 9 (17%) in the saline infusion plus NAC group, and in 7 (14%) in the SB infusion group.

CONCLUSIONS:

Our findings suggest that neither the addition of NAC nor the administration of SB add further benefit in CIN prevention, compared to standard hydration with isotonic saline infusion.

PMID:
20127900
PMCID:
PMC6653091
DOI:
10.1002/clc.20576
[Indexed for MEDLINE]
Free PMC Article

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