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Chem Commun (Camb). 2010 Feb 21;46(7):1156-8. doi: 10.1039/b912396b. Epub 2010 Jan 4.

Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level.

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1
Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

Abstract

Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Abeta(1-42) fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically.

PMID:
20126745
DOI:
10.1039/b912396b
[Indexed for MEDLINE]
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