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Diabet Med. 2010 Jan;27(1):113-6. doi: 10.1111/j.1464-5491.2009.02876.x.

Effect of L-arginine on the microcirculation in the neuropathic diabetic foot in Type 2 diabetes mellitus: a double-blind, placebo-controlled study.

Author information

1
Tameside Hospital NHS Foundation Trust, Ashton-under-Lyne, UK. Edward.jude@tgh.nhs.uk

Abstract

OBJECTIVE:

To investigate the effect of L-arginine on endothelial function, transcutaneous oxygen and clinical neuropathy in patients with peripheral neuropathy as a result of diabetes.

RESEARCH DESIGN AND METHODS:

Thirty diabetic patients with peripheral neuropathy were randomized to receive L-arginine (3 g three times daily) or placebo (3 g three times daily) for 3 months. All patients had foot microcirculation and foot transcutaneous oxygen pressure (TcPO(2)), neuropathy disability score (NDS) and vibration perception threshold (VPT) assessed at baseline and follow-up.

RESULTS:

No difference was observed in endothelium-dependent and -independent vasodilation, TcPO(2), NDS and VPT.

CONCLUSIONS:

L-arginine has no effect on endothelial dysfunction, TcPO(2) and clinical neuropathy.

[Indexed for MEDLINE]

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