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Anal Chem. 2010 Mar 1;82(5):1598-600. doi: 10.1021/ac9027388.

Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry.

Abstract

Over 60% of current pharmaceutical drugs have origins in natural products. To expand on current methods allowing one to characterize natural products directly from bacterial culture, herein we describe the use of desorption electrospray ionization (DESI) imaging mass spectrometry in monitoring the exchange of secondary metabolites between Bacillus subtilis and Streptomyces coelicolor using a simple imprinting technique.

PMID:
20121185
PMCID:
PMC4112561
DOI:
10.1021/ac9027388
[Indexed for MEDLINE]
Free PMC Article

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