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Int J Mol Sci. 2009 Aug 10;10(8):3517-30. doi: 10.3390/ijms10083517.

Antihypertensive properties of plant-based prebiotics.

Author information

1
Universiti Sains Malaysia, Penang, Malaysia. siokkoon85@yahoo.com

Abstract

Hypertension is one of the major risk factors for cardiovascular disease. Although various drugs for its treatment have been synthesized, the occurring side effects have generated the need for natural interventions for the treatment and prevention of hypertension. Dietary intervention such as the administration of prebiotics has been seen as a highly acceptable approach. Prebiotics are indigestible food ingredients that bypass digestion and reach the lower gut as substrates for indigenous microflora. Most of the prebiotics used as food adjuncts, such as inulin, fructooligosaccharides, dietary fiber and gums, are derived from plants. Experimental evidence from recent studies has suggested that prebiotics are capable of reducing and preventing hypertension. This paper will discuss some of the mechanisms involved, the evidence generated from both in-vitro experiments and in-vivo trials and some controversial findings that are raised.

KEYWORDS:

controversies; evidence; fiber; fos; gum; inulin; mechanism; prebiotics

PMID:
20111692
PMCID:
PMC2812835
DOI:
10.3390/ijms10083517
[Indexed for MEDLINE]
Free PMC Article

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