Send to

Choose Destination
J Med Microbiol. 2010 Apr;59(Pt 4):392-9. doi: 10.1099/jmm.0.008672-0. Epub 2010 Jan 28.

Probiotic Escherichia coli strain Nissle 1917 outcompetes intestinal pathogens during biofilm formation.

Author information

Microbial Genomics Group, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.


Many bacterial infections are associated with biofilm formation. Bacterial biofilms can develop on essentially all kinds of surfaces, producing chronic and often intractable infections. Escherichia coli is an important pathogen causing a wide range of gastrointestinal infections. E. coli strain Nissle 1917 has been used for many decades as a probiotic against a variety of intestinal disorders and is probably the best field-tested E. coli strain in the world. Here we have investigated the biofilm-forming capacity of Nissle 1917. We found that the strain was a good biofilm former. Not only was it significantly better at biofilm formation than enteropathogenic, enterotoxigenic and enterohaemorrhagic E. coli strains, it was also able to outcompete such strains during biofilm formation. The results support the notion of bacterial prophylaxis employing Nissle 1917 and may partially explain why the strain has a beneficial effect on many intestinal disorders.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ingenta plc
Loading ...
Support Center