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Biol Psychiatry. 2010 Jun 1;67(11):1033-9. doi: 10.1016/j.biopsych.2009.11.027. Epub 2010 Jan 27.

Seasonal changes in brain serotonin transporter binding in short serotonin transporter linked polymorphic region-allele carriers but not in long-allele homozygotes.

Author information

1
Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. Jan.kalbitzer@charite.de

Abstract

BACKGROUND:

A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been associated with seasonality both in patients with seasonal affective disorder and in the general population.

METHOD:

We used in vivo molecular imaging to measure cerebral serotonin transporter (5-HTT) binding in 57 healthy Scandinavians and related the outcome to season of the year and to the 5-HTTLPR carrier status.

RESULTS:

We found that the number of daylight minutes at the time of scanning correlated negatively with 5-HTT binding in the putamen and the caudate, with a similar tendency in the thalamus, whereas this association was not observed for the midbrain. Furthermore, in the putamen, an anatomic region with relatively dense serotonin innervation, we found a significant gene x daylight effect, such that there was a negative correlation between 5-HTT binding and daylight minutes in carriers of the short 5-HTTLPR allele but not in homozygote carriers of the long allele.

CONCLUSIONS:

Our findings are in line with S-carriers having an increased response in neural circuits involved in emotional processing to stressful environmental stimuli but here demonstrated as a endophenotype with dynamic changes in serotonin reuptake.

PMID:
20110086
DOI:
10.1016/j.biopsych.2009.11.027
[Indexed for MEDLINE]

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