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Semin Cell Dev Biol. 2010 May;21(3):255-9. doi: 10.1016/j.semcdb.2010.01.019. Epub 2010 Jan 28.

Mitotic functions of kinesin-5.

Author information

1
Department of Biology, University of Massachusetts, Amherst, Morrill Science Center, Amherst, MA 01003, United States.

Abstract

In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division.

PMID:
20109572
PMCID:
PMC2844466
DOI:
10.1016/j.semcdb.2010.01.019
[Indexed for MEDLINE]
Free PMC Article

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