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Cell Microbiol. 2010 Apr 1;12(4):424-31. doi: 10.1111/j.1462-5822.2010.01447.x. Epub 2010 Jan 26.

Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation.

Author information

1
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA. kristin.burns@nyumc.org

Abstract

Prokaryotic ubiquitin-like protein (Pup) is the first identified prokaryotic protein that is functionally analogous to ubiquitin. Despite using the proteasome as the end-point for proteolysis, Pup differs from ubiquitin both biochemically and structurally. We will discuss these differences that have been highlighted by several recent studies. Finally, we will speculate on the possible interactions between the two analogous pathways in pathogen and host.

PMID:
20109157
PMCID:
PMC3647454
DOI:
10.1111/j.1462-5822.2010.01447.x
[Indexed for MEDLINE]
Free PMC Article

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