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Nat Genet. 2010 Feb;42(2):100-1. doi: 10.1038/ng0210-100.

Deregulation of H3K27 methylation in cancer.

Abstract

A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.

PMID:
20104248
DOI:
10.1038/ng0210-100
[Indexed for MEDLINE]

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