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Am J Geriatr Psychiatry. 2010 Feb;18(2):172-6. doi: 10.1097/JGP.0b013e3181c2947f.

Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients.

Author information

1
Department and Institute of Psychiatry, Laboratory of Neuroscience-LIM 27, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.

Abstract

OBJECTIVE:

To assess the serum levels of interleukin 1beta (IL-1beta) in elderly depressed patients in comparison with nondepressed healthy elderly subjects.

DESIGN:

Cross-sectional study.

SETTING:

Tertiary memory clinic.

PARTICIPANTS:

Twenty-three antidepressant-free elderly depressed patients and 44 nondepressed healthy elderly comparison group were enrolled to this study.

MEASUREMENT:

Serum IL-1beta levels were determined with highly sensitive colorimetric sandwich enzyme-linked immunosorbent assay. Severity of the depressive episode was determined by scores on the Hamilton Depression Scale-21 item and cognitive performance by the scores on the Cambridge Cognition Examination, Mini Mental State Examination clock drawing test, and verbal fluency.

RESULTS:

IL-1beta serum levels were increased in elderly patients versus nondepressed elderly (t = 2.21, df = 65, p = 0.04). After categorizing elderly depressed subjects into late onset (LOD) versus early onset (EOD), patients with EOD had the highest IL-1beta levels, when compared with nondepressed elderly patients and patients with LOD in analysis of variance (F = 4.9, df = 2, 64, p <0.01).

CONCLUSIONS:

Late-life depression is associated with higher IL-1beta levels suggesting that increased proinflammatory state may play a role in the physiopathology of depression in the elderly. The authors further show that this might be more prominent in those patients with EOD geriatric depression.

PMID:
20104073
DOI:
10.1097/JGP.0b013e3181c2947f
[Indexed for MEDLINE]
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