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FEBS Lett. 2010 Mar 5;584(5):968-72. doi: 10.1016/j.febslet.2010.01.040. Epub 2010 Jan 26.

C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase.

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Department of Biochemistry, School of Medicine, Dongguk University, Kyungju 780-714, Republic of Korea.

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  • FEBS Lett. 2010 Jun 3;584(11):2491.


C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.

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