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Indian J Dermatol. 2009;54(4):323-9. doi: 10.4103/0019-5154.57606.

Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in Wistar rats.

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Department of Physiotherapy, Manipal Medical College, Manipal, India.



Generally, the significances of laser photo stimulation are now accepted, but the laser light facilitates wound healing and tissue repair remains poorly understood.


We have examined the hypothesis that the laser photo stimulation can enhance the collagen production in diabetic wounds using the excision wound model in the Wistar rat model.


The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N = 24) wound was treated with 632.8 nm He-Ne laser at a dose of 3-9 J/cm(2) for 5 days a week until the wounds healed completely. The control group was sham irradiated.


A significant increase in the hydroxyproline content and reduction in the wound size were observed in the study group. The pro-healing actions seem to be due to increased collagen deposition as well as better alignment and maturation.


The biochemical analysis and clinical observation suggested that 3-6 J/cm(2) laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.


Clinical observation; hydroxyproline; laser photo stimulation; photo inhibition; wound healing

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