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Indian J Dermatol. 2009;54(4):323-9. doi: 10.4103/0019-5154.57606.

Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in Wistar rats.

Author information

1
Department of Physiotherapy, Manipal Medical College, Manipal, India. arun.maiya@manipal.edu

Abstract

BACKGROUND:

Generally, the significances of laser photo stimulation are now accepted, but the laser light facilitates wound healing and tissue repair remains poorly understood.

AIMS:

We have examined the hypothesis that the laser photo stimulation can enhance the collagen production in diabetic wounds using the excision wound model in the Wistar rat model.

METHODS:

The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N = 24) wound was treated with 632.8 nm He-Ne laser at a dose of 3-9 J/cm(2) for 5 days a week until the wounds healed completely. The control group was sham irradiated.

RESULT:

A significant increase in the hydroxyproline content and reduction in the wound size were observed in the study group. The pro-healing actions seem to be due to increased collagen deposition as well as better alignment and maturation.

CONCLUSION:

The biochemical analysis and clinical observation suggested that 3-6 J/cm(2) laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.

KEYWORDS:

Clinical observation; hydroxyproline; laser photo stimulation; photo inhibition; wound healing

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