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Antimicrob Agents Chemother. 2010 Apr;54(4):1613-5. doi: 10.1128/AAC.01637-09. Epub 2010 Jan 25.

Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and -resistant Acinetobacter baumannii isolates.

Author information

1
Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany. paul.higgins@uni-koeln.de

Abstract

This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH, and that of ciprofloxacin against Acinetobacter baumannii under standard conditions (pH 7.2) and at a pH of 5.8. Overall, finafloxacin demonstrated superior activity to ciprofloxacin under acidic conditions. Furthermore, finafloxacin showed comparable activity to ciprofloxacin at pH 7.2. Hence, finafloxacin could be a promising new antimicrobial agent for the treatment of A. baumannii infections at acidic body compartments.

PMID:
20100879
PMCID:
PMC2849356
DOI:
10.1128/AAC.01637-09
[Indexed for MEDLINE]
Free PMC Article

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