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J Sep Sci. 2010 Feb;33(3):410-21. doi: 10.1002/jssc.200900653.

Chromatographic fingerprinting and related chemometric techniques for quality control of traditional Chinese medicines.

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Research Center of Modernization of Chinese Medicines, Central South University, Changsha, PR China.


Development of chromatographic fingerprint (CF) and related chemometric methods and their applications to quality control of traditional Chinese medicines (TCMs) were discussed. CF is essentially a kind of quality control method for TCMs (or Chinese herbal medicines). Also, it is a quality-relevant-data high-throughput and integral tool to explore chemically the complexity of TCMs. With the help of chemometrics, some difficulties in evaluation and analysis of CFs, such as calculation of information content, peak alignment, pattern analysis, deconvolution of overlapping peaks, etc. could be well solved. To further explore TCMs synergic quality, intensive study of CF coupled with chemometrics will create the possibility to achieve the aim to reveal the working mechanisms of TCMs and to further control and strengthen TCMs' intrinsic quality in a comprehensive manner.

[Indexed for MEDLINE]

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