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Mar Drugs. 2009 Nov 3;7(4):528-38. doi: 10.3390/md7040528.

Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena.

Author information

1
Department of Medicinal Chemistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA. jkwan@ufl.edu

Abstract

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8-10 (1-3). The structures of 1-3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1-3 are closely related to lyngbyastatins 4-7. Like the latter compounds, we found 1-3 to inhibit porcine pancreatic elastase, with IC(50) values of 123 nM, 210 nM and 120 nM, respectively.

KEYWORDS:

Lyngbya semiplena; cyanobacteria; cyclic depsipeptides; elastase inhibitors; lyngbyastatins

PMID:
20098596
PMCID:
PMC2810234
DOI:
10.3390/md7040528
[Indexed for MEDLINE]
Free PMC Article

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