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Plant Cell. 2010 Jan;22(1):34-47. doi: 10.1105/tpc.109.072819. Epub 2010 Jan 22.

Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis.

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  • 1Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, 1030 Viena, Austria.

Abstract

Epigenetic changes of gene expression can potentially be reversed by developmental programs, genetic manipulation, or pharmacological interference. However, a case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis thaliana plants, created an epiallele resistant to many mutations or inhibitor treatments that activate many other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetics and drug application provides evidence for an epigenetic double lock that is only alleviated upon the simultaneous removal of both DNA methylation and histone methylation. Therefore, the cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic states and contributes to heritable diversity of gene expression patterns.

PMID:
20097869
PMCID:
PMC2828703
DOI:
10.1105/tpc.109.072819
[PubMed - indexed for MEDLINE]
Free PMC Article
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