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Enferm Infecc Microbiol Clin. 2010 May;28(5):278-83. doi: 10.1016/j.eimc.2009.09.004. Epub 2010 Jan 25.

[Plasma antiretroviral levels in children with human immunodeficiency virus infection. Influence of sex and age].

[Article in Spanish]

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Servicio de Pediatría-Infecciosas, Hospital Universitario La Paz, Madrid, España.



Pharmacologic studies have shown a relationship between plasma antiretroviral levels and toxicity/viral activity. Nevertheless, pharmacokinetic and pharmacodynamic data are inconsistent and limited in HIV-infected children. An analysis was performed of plasma antiretroviral concentrations in clinical practice and their influence on therapy efficacy in HIV-infected children.


Observational, prospective, multicenter study, including HIV-infected children followed up at 5 reference hospitals between March 2006 and June 2008. Pre-dose plasma antiretroviral levels were determined and the relationships with various clinical and analytical variables were investigated.


A total of 129 patients were included, and 41.3% had antiretroviral plasma levels outside the established range. No differences were found between sexes. Children younger than 1 year had a higher rate of suboptimal levels and higher viral load than the remaining children.


Antiretroviral plasma concentrations are more frequently suboptimal in children younger than 1 year. This finding is related with greater viral failure and implies a considerable challenge in this population, which requires very long-term treatment.

[Indexed for MEDLINE]

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