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DNA Repair (Amst). 2010 Mar 2;9(3):202-9. doi: 10.1016/j.dnarep.2009.12.009. Epub 2010 Jan 22.

Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival.

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1
Molecular Biology Program, Weill-Cornell Graduate School of Medical Sciences, New York, NY, USA. cbg2002@med.cornell.edu

Abstract

PriA, a 3'-->5' superfamily 2 DNA helicase, acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. The ability of PriA to initiate replication at stalled forked structures ensures complete genome replication and helps to protect the cell from illegitimate recombination events. This review focuses on the activities of PriA and its role in replication fork assembly and maintaining genomic integrity.

PMID:
20097140
PMCID:
PMC2827650
DOI:
10.1016/j.dnarep.2009.12.009
[Indexed for MEDLINE]
Free PMC Article
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