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Physiol Behav. 2010 Jun 1;100(3):234-8. doi: 10.1016/j.physbeh.2010.01.004. Epub 2010 Jan 22.

Mini-review: impact of recurrent hypoglycemia on cognitive and brain function.

Author information

1
Department of Psychology and Center for Neuroscience Research, University at Albany, Albany, NY 12222, USA. emcnay@albany.edu

Abstract

Recurrent hypoglycemia (RH), the most common side-effect of intensive insulin therapy for diabetes, is well established to diminish counter-regulatory responses to further hypoglycemia. However, despite significant patient concern, the impact of RH on cognitive and neural function remains controversial. Here we review the data from both human studies and recent animal studies regarding the impact of RH on cognitive, metabolic, and neural processes. Overall, RH appears to cause brain adaptations which may enhance cognitive performance and fuel supply when euglycemic but which pose significant threats during future hypoglycemic episodes.

PMID:
20096711
PMCID:
PMC2860007
DOI:
10.1016/j.physbeh.2010.01.004
[Indexed for MEDLINE]
Free PMC Article

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