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FEBS Lett. 2010 Apr 2;584(7):1417-26. doi: 10.1016/j.febslet.2010.01.009. Epub 2010 Jan 22.

Autophagy in cellular growth control.

Author information

1
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Cell growth is regulated by two antagonistic processes: TOR signaling and autophagy. These processes integrate signals including growth factors, amino acids, and energy status to ensure that cell growth is appropriate to environmental conditions. Autophagy responds indirectly to the cellular milieu as a downstream inhibitory target of TOR signaling and is also directly controlled by nutrient availability, cellular energy status, and cell stress. The control of cell growth by TOR signaling and autophagy are relevant to disease, as altered regulation of either pathway results in tumorigenesis. Here we give an overview of how TOR signaling and autophagy integrate nutritional status to regulate cell growth, how these pathways are coordinately regulated, and how dysfunction of this regulation might result in tumorigenesis.

PMID:
20096689
PMCID:
PMC2856449
DOI:
10.1016/j.febslet.2010.01.009
[Indexed for MEDLINE]
Free PMC Article

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