Format

Send to

Choose Destination
DNA Repair (Amst). 2010 Mar 2;9(3):325-30. doi: 10.1016/j.dnarep.2010.01.006. Epub 2010 Jan 21.

Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.

Author information

1
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA. yilun.liu@yale.edu

Abstract

RECQ proteins are conserved DNA helicases in both prokaryotes and eukaryotes. The importance of the RECQ family helicases in human health is demonstrated by their roles as cancer suppressors that are vital for preserving genome integrity. Mutations in one of the RECQ family proteins, RECQ4, not only result in developmental abnormalities and cancer predispositions, but are also linked to premature aging. Therefore, defining the function and regulation of the RECQ4 protein is fundamental to our understanding of both the aging process and cancer pathogenesis. This review will summarize the clinical effect of RECQ4 in human health, and discuss the recent progress and debate in defining the complex molecular function of RECQ4 in DNA metabolism.

PMID:
20096650
DOI:
10.1016/j.dnarep.2010.01.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center