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Respir Physiol Neurobiol. 2010 Aug 31;173 Suppl:S37-42. doi: 10.1016/j.resp.2010.01.007. Epub 2010 Jan 21.

Leptin integrates vertebrate evolution: from oxygen to the blood-gas barrier.

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Department of Pediatrics, University of California-Los Angeles, CA, USA.


The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany. The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species; to delineate the interrelationship between the evolution of the blood-gas barrier, locomotion and metabolism; to introduce the selection pressures for the evolution of the surfactant system as a key to understanding the physiology of the blood-gas barrier; to introduce the lung lipofibroblast and its product, leptin, which coordinately regulates pulmonary surfactant, type IV collagen in the basement membrane and host defense, as the cell-molecular site of selection pressure for the blood-gas barrier; to drill down to the gene regulatory network(s) involved in leptin signaling and the blood-gas barrier phenotype; to extend the relationship between leptin and the blood-gas barrier to diving mammals.

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