Format

Send to

Choose Destination
Mol Biosyst. 2010 Feb;6(2):336-8. doi: 10.1039/b923177c. Epub 2009 Dec 22.

Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.

Abstract

Spectinabilin is a rare nitrophenyl-substituted polyketide metabolite. Here we report the cloning and heterologous expression of the spectinabilin gene cluster from Streptomyces spectabilis. Unexpectedly, this gene cluster is evolutionarily closer to the aureothin gene cluster than to the spectinabilin gene cluster from Streptomyces orinoci. Moreover, the two nearly identical spectinabilin gene clusters use a distinctly different regulation mechanism.

PMID:
20094652
DOI:
10.1039/b923177c
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center