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Nat Rev Mol Cell Biol. 2010 Feb;11(2):149-55. doi: 10.1038/nrm2834.

Understanding cytokinesis: lessons from fission yeast.

Author information

1
Thomas D. Pollard is at the Department of Molecular Cellular and Developmental Biology, and the Departments of Molecular Biophysics and Biochemistry and of Cell Biology, Yale University, PO BOX 208103, New Haven, Connecticut 06520-8103, USA.

Abstract

For decades after the discovery that a contractile ring made of actin filaments and myosin II produces the force to constrict the cleavage furrow of animal cells, the complexity of cytokinesis has slowed progress in understanding the mechanism. Mechanistic insights, however, have been obtained by genetic, biochemical, microscopic and mathematical modelling approaches in the fission yeast Schizosaccharomyces pombe. Many features that have been identified in fission yeast are probably shared with animal cells, as both inherited many cytokinesis genes from their common ancestor about one billion years ago.

PMID:
20094054
PMCID:
PMC2819279
DOI:
10.1038/nrm2834
[Indexed for MEDLINE]
Free PMC Article

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