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Nat Rev Mol Cell Biol. 2010 Feb;11(2):103-12. doi: 10.1038/nrm2847.

PKC and the control of localized signal dynamics.

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Protein Phosphorylation Laboratory, London Research Institute Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.


Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C (PKC) family, have been increasingly implicated in the organization of signal propagation, particularly in the spatial distribution of signals. Examples of where and how various PKC isoforms direct this tier of signal organization are becoming more evident.

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