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Obstet Gynecol. 2010 Feb;115(2 Pt 2):442-5. doi: 10.1097/AOG.0b013e3181cb9955.

Term stillbirth caused by oral Fusobacterium nucleatum.

Author information

1
Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4905, USA. yiping.han@case.edu

Abstract

BACKGROUND:

Intrauterine infection is a recognized cause of adverse pregnancy outcome, but the source of infection is often undetermined. We report a case of stillbirth caused by Fusobacterium nucleatum that originated in the mother's mouth.

CASE:

A woman with pregnancy-associated gingivitis experienced an upper respiratory tract infection at term, followed by stillbirth a few days later. F. nucleatum was isolated from the placenta and the fetus. Examination of different microbial floras from the mother identified the same clone in her subgingival plaque but not in the supragingival plaque, vagina, or rectum.

CONCLUSION:

F. nucleatum may have translocated from the mother's mouth to the uterus when the immune system was weakened during the respiratory infection. This case sheds light on patient management for those with pregnancy-associated gingivitis.

PMID:
20093874
PMCID:
PMC3004155
DOI:
10.1097/AOG.0b013e3181cb9955
[Indexed for MEDLINE]
Free PMC Article

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