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Curr Opin Genet Dev. 2010 Feb;20(1):41-50. doi: 10.1016/j.gde.2009.12.001. Epub 2010 Jan 21.

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.

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1
Ontario Cancer Institute, Campbell Family Institute for Breast Cancer Research, Dept. of Medical Biophysics, University of Toronto, Toronto, Canada.

Abstract

In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.

PMID:
20093003
PMCID:
PMC3015045
DOI:
10.1016/j.gde.2009.12.001
[Indexed for MEDLINE]
Free PMC Article
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