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Biopolymers. 2010;94(1):32-48. doi: 10.1002/bip.21333.

Protein- and peptide-modified synthetic polymeric biomaterials.

Author information

1
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.

Abstract

This review presents an overview on bio-hybrid approaches of integrating the structural and functional features of proteins and peptides with synthetic polymers and the resulting unique properties in such hybrids, with a focus on bioresponsive/bioactive systems with biomaterials applications. The review is divided in two broad sections. First, we describe several examples of bio-hybrids produced by combining versatile synthetic polymers with proteins/enzymes and drugs that have resulted in (1) hybrid materials based on responsive polymers, (2) responsive hydrogels based on enzyme-catalyzed reactions, protein-protein interactions and protein-drug sensing, and (3) dynamic hydrogels based on conformational changes of a protein. Next, we present hybrids produced by combining synthetic polymers with peptides, classified based on the properties of the peptide domain: (1) peptides with different conformations, such as alpha-helical, coiled-coil, and beta-sheet; (2) peptides derived from structural protein domains such as silk, elastin, titin, and collagen; and (3) peptides with other biofunctional properties such as cell-binding domains and enzyme-recognized degradation domains.

PMID:
20091878
PMCID:
PMC4437713
DOI:
10.1002/bip.21333
[Indexed for MEDLINE]
Free PMC Article

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