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J Genet. 2009 Dec;88(4):495-515.

Mediators of ocular angiogenesis.

Author information

1
Department of Ophthalmology, John Moran Eye Center, University of Utah, Salt Lake City, UT-84132, USA.

Abstract

Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.

PMID:
20090210
PMCID:
PMC3306772
[Indexed for MEDLINE]
Free PMC Article

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