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Curr Alzheimer Res. 2010 May;7(3):197-9.

Bridging neurocognitive aging and disease modification: targeting functional mechanisms of memory impairment.

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Department of Psychological and Brain Science, Johns Hopkins University, Baltimore, MD 21218, USA.


Risk for Alzheimer's disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a person's age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimer's disease.

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