Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Alzheimer Res. 2010 May;7(3):197-9.

Bridging neurocognitive aging and disease modification: targeting functional mechanisms of memory impairment.

Author information

1
Department of Psychological and Brain Science, Johns Hopkins University, Baltimore, MD 21218, USA. michela@jhu.edu

Abstract

Risk for Alzheimer's disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a person's age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimer's disease.

PMID:
20088811
PMCID:
PMC3008592
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Bentham Science Publishers Ltd. Icon for PubMed Central
    Loading ...
    Support Center