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J Interv Card Electrophysiol. 2010 Mar;27(2):127-35. doi: 10.1007/s10840-009-9454-z. Epub 2010 Jan 20.

Prospective multicenter randomized trial of fast ventricular tachycardia termination by prolonged versus conventional anti-tachyarrhythmia burst pacing in implantable cardioverter-defibrillator patients-Atp DeliVery for pAiNless ICD thErapy (ADVANCE-D) Trial results.

Author information

1
Ospedale S. Filippo Neri, Roma, Italy. m.santini@rmnet.it

Erratum in

  • J Interv Card Electrophysiol. 2010 Oct;29(1):73.

Abstract

PURPOSE:

The purpose of the trial was to quantify and compare the efficacy of two different sequences of burst anti-tachycardia pacing (ATP) strategies for the termination of fast ventricular tachycardia.

METHODS:

The trial was prospective, multicenter, parallel and randomized, enrolling patients with an indication for implantable cardioverter-defibrillator implantation.

RESULTS:

From February 2004, 925 patients were randomized and followed-up for 12 months. Eight pulses ATP terminated 64% of episodes vs. 70% in the 15-pulse group (p = 0.504). Fifteen pulses proved significantly better in patients without a previous history of heart failure (p = 0.014) and in patients with LVEF >or= 40% (p = 0.016). No significant differences between groups were observed with regard to syncope/near-syncope occurrence.

CONCLUSION:

In the general population, 15-pulse ATP is as effective and safe as eight-pulse ATP. The efficacy of ATP on fast ventricular arrhythmias confirmed once more the striking importance of careful device programming in order to reduce painful shocks.

PMID:
20087760
PMCID:
PMC2836470
DOI:
10.1007/s10840-009-9454-z
[Indexed for MEDLINE]
Free PMC Article
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