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Cancer Causes Control. 2010 May;21(5):737-43. doi: 10.1007/s10552-010-9502-0. Epub 2010 Jan 20.

Human papillomavirus is not associated with colorectal cancer in a large international study.

Author information

1
Department of Human Genetics, School of Medicine, University of Michigan, 109 Zina Pitcher, Ann Arbor, MI 48109-2200, USA.

Abstract

OBJECTIVE OF THE STUDY:

Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer.

METHODS:

The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15).

RESULTS:

All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method.

CONCLUSIONS:

We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

PMID:
20087645
PMCID:
PMC4269349
DOI:
10.1007/s10552-010-9502-0
[Indexed for MEDLINE]
Free PMC Article

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