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Int J Mol Sci. 2009 Nov 4;10(11):4742-53. doi: 10.3390/ijms10114742.

Antinociceptive and anti-inflammatory effects of ethanolic extracts of Glycine max (L.) Merr and Rhynchosia nulubilis seeds.

Author information

1
Korea Food Research Institute, Seongnam, Kyonggi, Korea. jlunar@naver.com

Abstract

The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti-inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.

KEYWORDS:

Glycine max; Rhynchosia nulubilis; anti-inflammatory activity; anti-nociceptive activity

PMID:
20087462
PMCID:
PMC2808008
DOI:
10.3390/ijms10114742
[Indexed for MEDLINE]
Free PMC Article
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