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Nat Rev Neurosci. 2010 Feb;11(2):100-13. doi: 10.1038/nrn2774.

Abnormal neural oscillations and synchrony in schizophrenia.

Author information

  • 1Department of Neurophysiology, Max-Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany. uhlhaas@mpihfrankfurt.mpg.de

Abstract

Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (gamma-aminobutyric acid) interneurons and in cortico-cortical connections.

PMID:
20087360
DOI:
10.1038/nrn2774
[PubMed - indexed for MEDLINE]
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