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Neuroreport. 2010 Mar 10;21(4):268-72. doi: 10.1097/WNR.0b013e328335b411.

The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease.

Author information

1
Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

This study was undertaken to investigate the neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) on 6-hydroxydopamine (6-OHDA)-induced rats with Parkinson's disease. rTMS was given to rats with Parkinson's disease induced by 6-OHDA, daily for 4 weeks to examine the protective effects. Rotational test showed that rTMS significantly attenuated apomorphine-induced turns in rats with Parkinson's disease. Tissue processing showed that rTMS alleviated 6-OHDA-induced loss of dopaminergic neurons in rat substantia nigra. Furthermore, rTMS decreased the levels of cyclooxygenase-2 and tumor necrosis factor-alpha in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with Parkinson's disease.

PMID:
20087233
DOI:
10.1097/WNR.0b013e328335b411
[Indexed for MEDLINE]

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