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Cell Stem Cell. 2010 Jan 8;6(1):3-4. doi: 10.1016/j.stem.2009.12.013.

Fine-tuning silencing.

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Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.


Polycomb Repressive Complex 2 (PRC2) modifies chromatin to silence many embryonic patterning genes, restricting their expression to the appropriate cell populations. Two reports in Cell by Peng et al. (2009) and Shen et al. (2009) identify Jarid2/Jumonji, a new component of PRC2, which inhibits PRC2 enzymatic activity to fine-tune silencing.

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